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Sensitization of cells to ionizing radiation by chlorin e6Na

✍ Scribed by Yoshio Hosoi; Mieko Kawamura; Tatsuo Ido; Yoshihiro Takai; Keiichiro Ishii; Kenji Nemoto; Tetuya Ono; Shuichi Kimura; Kiyohiko Sakamoto

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
164 KB
Volume
6
Category
Article
ISSN
1065-7541

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✦ Synopsis

We have investigated whether a hydrophilic photosensitizer, chlorin e6Na (Ce6Na), can sensitize cells to ionizing radiation. When V79-1 cells were pretreated with Ce6Na for 2 hr before receiving a dose of 2-14 Gy of irradiation, the cells became sensitive to X-irradiation. The sensitizing effect of Ce6Na depended on the dose of Ce6Na. The sensitizing effect also depended on the length of the treatment period before X-irradiation up to 4 hr, but not on the length of a treatment period after X-irradiation. Intracellular concentrations of Ce6Na were increased linearly after incubation with Ce6Na for periods of up to 4 h. The dose-modifying factor calculated from the survival curve was 1.25.

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