Synthesis of antibody by spleen cells after exposure to kiloroentgen doses of ionizing radiation

✍ Scribed by T. Makinodan; Paul Nettesheim; Toshiteru Morita; Carol J. Chadwick

• Publisher: John Wiley and Sons
• Year: 1967
• Tongue: English
• Weight: 939 KB
• Volume: 69
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040690312

✦ Synopsis

Mouse spleen cells in diffusion chambers were studied in an effort to assess the radiation survival curves of lymphoid cells during the different serological phases of immune response and to characterize morphologically and metabolically these radiation-resistant cells. The results showed that the capacity of immunocompetent progenitor cells to proliferate and differentiate into antibody-synthesizing cells was highly sensitive to x-irradiation. Their fully differentiated progenies, which were made up mainly of mature plasma cells, were resistant in that they were able to synthesize antibody effectively for as long as several days after their exposure to radiation doses up to 10,000 R.