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Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan

✍ Scribed by Déjosez, M; Ramp, U; Mahotka, C; Krieg, A; Walczak, H; Gabbert, H E; Gerharz, C D


Book ID
110016118
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
274 KB
Volume
7
Category
Article
ISSN
1350-9047

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Enhancement of TRAIL/Apo2L-mediated apop
✍ Xiu-Xian Wu; Yoshiyuki Kakehi; Youichi Mizutani; Hiroyuki Nishiyama; Toshiyuki K 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 639 KB

## Abstract Renal cell carcinoma (RCC) is one of the most drug‐resistant malignancies in humans. We show that adriamycin (ADR) and TNF‐related apoptosis‐inducing ligand (TRAIL)/Apo2L have a synergistic cytotoxic effect against RCC cells. This synergistic cytotoxicity was obtained in ACHN, A704, Cak