## Abstract Renal cell carcinoma (RCC) is one of the most drug‐resistant malignancies in humans. We show that adriamycin (ADR) and TNF‐related apoptosis‐inducing ligand (TRAIL)/Apo2L have a synergistic cytotoxic effect against RCC cells. This synergistic cytotoxicity was obtained in ACHN, A704, Cak
✦ LIBER ✦
Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2
✍ Scribed by Kyoung-jin Min; Ji Hoon Jang; Jung Tae Lee; Kyeong Sook Choi; Taeg Kyu Kwon
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 650 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0946-2716
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## Abstract Despite improvements in chemotherapy and surgery in the treatment of osteosarcoma (OS), satisfactory results are still difficult to achieve. Novel therapeutic modalities need to be developed for osteosarcoma treatment. The combined effects of tumor necrosis factor‐related apoptosis‐indu