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Sensitivity of testis tumour cells to chemotherapeutic drugs: Role of detoxifying pathways

✍ Scribed by J.R.W. Masters; R. Thomas; A.G. Hall; L. Hogarth; E.C. Matheson; A.R. Cattan; H. Lohrer

Book ID
116167863
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
701 KB
Volume
32
Category
Article
ISSN
0959-8049

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Testicular germ cell tumoun (TGCT) are cured in over 80% of patients by using combination chemotherapy. However, the mechanism regulating this sensitivity has not been defined. Because cells derived from patients with DNA repair syndromes are similar to TCGT in their sensitivity to certain DNA-damag