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Hypersensitivity of human testis-tumour cell lines to chemotherapeutic drugs

✍ Scribed by John R. W. Masters; Edward J. Osborne; M. Claire Walker; Christopher N. Parris

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
670 KB
Volume
53
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Metastatic testis tumours, in contrast to most other types of cancer, can be cured by drugs. To investigate which classes of chemotherapeutic drug are differentially toxic to testis‐tumour cells, we compared the in vitro dose‐response curves of 5 human testis and 5 bladder‐cancer cell lines to 12 compounds. The testis cells were hypersensitive to drugs that interact directly with DNA (m‐amsa, bleomycin, cisplatin, doxorubicin, methylni‐ trosourea, mitozolomide, etoposide, mitomycin‐C), but little or no difference between the 2 cell types was seen following exposure to drugs whose mechanisms of action do not involve direct interaction with DNA (methotrexate, 5‐fluorouracil, colchicine, vinblastine). We conclude that testis tumour cells are either less tolerant of, or have a reduced capacity to repair, DNA damage.

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