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Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: a simple model

✍ Scribed by Geneviève Dupont; Gérald Houart; Paul De Koninck


Book ID
114117823
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
312 KB
Volume
34
Category
Article
ISSN
0143-4160

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CaM kinase II as frequency decoder of Ca
✍ Geneviève Dupont; Albert Goldbeter 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 69 KB

In many cell types, Ca2+ signals are organized in the form of repetitive spikes. The frequency of these intracellular Ca2+ oscillations increases with the level of stimulation, suggesting the existence of a frequency encoding phenomenon. The question arises as to how the frequency of Ca2+ oscillatio