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Sensitivity of Bloom's syndrome lymphocytes to ethyl methanesulfonate

โœ Scribed by Alena B. Krepinsky; J. A. Heddle; J. German

Publisher
Springer
Year
1979
Tongue
English
Weight
357 KB
Volume
50
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

Ethyl methanesulfonate induced several times as many sister. chromatid exchanges (SCEs) in lymphocytes from individuals affected with Bloom's syndrome as in lymphocytes from controls or heterozygotes. In cultures of cells from an individual with Bloom's syndrome who had two populations of lymphocytes circulating in his blood--'low' cells having normal spontaneous frequencies of SCEs and 'high' cells having elevated frequencies--only the high cells showed the increased sensitivity to ethyl methanesulfonate.

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