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Sensitive, Selective, and Irreversible Inhibition of Cyclooxygenase-2 Activity by Copper

✍ Scribed by Seiichi Nagano; Ashley I. Bush


Book ID
102101544
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
197 KB
Volume
3
Category
Article
ISSN
1860-7179

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Selective inhibition of cyclooxygenase (
✍ Kentaro Yazawa; Nelson H. Tsuno; Joji Kitayama; Kazushige Kawai; Yurai Okaji; Ma 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 336 KB

High-level expression of cyclooxygenase (COX)-2 is reported in 80 -90% of colorectal adenocarcinomas. Selective inhibition of COX-2 was shown to reduce colorectal tumorigenesis in different models of carcinogenesis and to prevent metastasis in xenograft tumor models, as well as to suppress in vitro