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Sensitive high-performance liquid chromatographic method for the determination of the lactone form and the lactone plus hydroxy-acid forms of the new camptothecin derivative DX-8951 in human plasma using fluorescence detection

โœ Scribed by Toshihiro Oguma; Yumi Ohshima; Minoru Nakaoka


Book ID
108447570
Publisher
Elsevier Science
Year
2000
Weight
211 KB
Volume
740
Category
Article
ISSN
0378-4347

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High-Performance Liquid Chromatographic
โœ Gary Boyd; John F. Smyth; Duncan I. Jodrell; Jeffrey Cummings ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 97 KB

## Analysis of camptothecins in biologic media is hampered by chemical hydrolysis of the parent lactone (form I) to an inactive hydroxy acid (form II). A solidphase extraction (SPE) method utilizing C2 -bonded silica particles (100 mg, 1 ml) is presented for simultaneous determination of forms I a