𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Senna. A safe and effective drug

✍ Scribed by N. Mascolo; R. Capasso; F. Capasso

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
74 KB
Volume
12
Category
Article
ISSN
0951-418X

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✦ Synopsis

Senna consists of the dried leaves and fruits of Cassia acutifolia and C. angustifolia. The principal active constituents of senna are dianthrone glycosides whose aglycone is rhein. Rhein-induced laxative effects occur through two distinct mechanisms: an increase in intestinal fluid transport and an increase in intestinal motility. Senna taken in recommended doses may lead to abdominal complaints whilst prolonged use causes melanosis coli. In recent years mutagenic effects of anthraquinone glycosides have been proven in in vitro tests, however studies in vivo do not confirm this for senna.

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