Sendai virus-specific T cell clones. II. Induction of interferon production by Sendai virus-specific T helper cell clones

✍ Scribed by Hildegund C. J. Ertl; Earl G. Brown; Robert W. Finberg

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 338 KB
• Volume: 12
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830121212

✦ Synopsis

Abstract

Interferon (IFN) was detected upon co‐culture of cloned Sendai virus (SV)‐specific T lymphocyte with SV‐presenting syngeneic stimulator cells. The antiviral activity was defined as IFN‐α, β. The T cell clones, upon contact with antigen‐presenting stimulator cells, stimulated adherent cells present in the stimulator cell population to secrete IFN. Induction of IFN production was independent from interleukin 2 production by the T cell clones.