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Semisynthesis of Human Somatotropin Analogs

✍ Scribed by Choh Hao Li and James Blake

Book ID
123656016
Publisher
National Academy of Sciences
Year
1979
Tongue
English
Weight
785 KB
Volume
76
Category
Article
ISSN
0027-8424

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The trypsin-catalyzed coupling of bovine (Boc)z-desoctapeptide (B23-B30)-insulin with synthetic octapeptides, H-Gly-Xz-X3-X4-Thr-Pro-Lys(Boc)-Thr-OH (Xz = Phe or Ala, X3 = Phe or Ala, X4 = Tyr or Ala), followed by deprotection and purification produced the [AlaBZ4, ThrB30]-, [AlaBZ5, ThrBN] -, and [