Enzymatic Semisynthesis of Dicarba Analogs of Calcitonin
✍ Scribed by Václav čeřovský; Erich Wünsch; Johann Brass
- Book ID
- 115132416
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 787 KB
- Volume
- 247
- Category
- Article
- ISSN
- 1432-1327
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The trypsin-catalyzed coupling of bovine (Boc)z-desoctapeptide (B23-B30)-insulin with synthetic octapeptides, H-Gly-Xz-X3-X4-Thr-Pro-Lys(Boc)-Thr-OH (Xz = Phe or Ala, X3 = Phe or Ala, X4 = Tyr or Ala), followed by deprotection and purification produced the [AlaBZ4, ThrB30]-, [AlaBZ5, ThrBN] -, and [
## Abstract Peptide bond formation can be enzymatically catalysed by the reverse reaction of proteases. Application is seen in the industrial production of human insulin. Human insulin derivative can be enzymatically prepared using either porcine insulin or the single chain B(1–29)‐A(1–21) insulin