Semisynthesis of D-ring-modified taxoids: thietane derivatives from taxine B

✍ Scribed by Christophe Payré; Ali Al Mourabit; Ludovic Mercklé; Alain Ahond; Christiane Poupat; Pierre Potier

• Book ID: 104210440
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 136 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00727-9

✦ Synopsis

The semisynthesis of 7-deoxobaccatin III derivatives, in which the oxygen atom in ring D is substituted for a sulfur atom, is presented; the starting material is the natural taxine B and isotaxine B extracted from the needles of Taxus baccata.