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Semisynthesis of D-Ring Modified Taxoids: Novel Thia Derivatives of Docetaxel

✍ Scribed by Mercklé,, Ludovic; Dubois, Joëlle; Place, Estelle; Thoret, Sylviane; Guéritte, Françoise; Guénard, Daniel; Poupat, Christiane; Ahond, Alain; Potier, Pierre

Book ID
120442477
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
116 KB
Volume
66
Category
Article
ISSN
0022-3263

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Semisynthesis of D-ring-modified taxoids
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✍ Christophe Payré; Ali Al Mourabit; Ludovic Mercklé; Alain Ahond; Christiane Poup 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 136 KB

The semisynthesis of 7-deoxobaccatin III derivatives, in which the oxygen atom in ring D is substituted for a sulfur atom, is presented; the starting material is the natural taxine B and isotaxine B extracted from the needles of Taxus baccata.