Semisynthesis of a Glycosylphosphatidylinositol-Anchored Prion Protein
✍ Scribed by Christian F. W. Becker; Xinyu Liu; Diana Olschewski; Riccardo Castelli; Ralf Seidel; Peter H. Seeberger
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 543 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0044-8249
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A large fraction of glycosylphosphatidylinositol (GPI)-anchored proteins and Src-like kinases are confined to glycolipid-enriched membrane (GEM) microdomains. The particular membrane topology of GPI-anchored proteins has led to the postulation of the existence of integral membrane proteins linking e
## Abstract The first total synthesis of a glycosylphosphatidylinositol (GPI) anchor bearing a polyunsaturated arachidonoyl fatty acid is reported. This lipid is found in mammalian GPIs that do not undergo lipid remodeling, a process that has important implications in the localization and function