Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei
✍ Scribed by Daniel K. Baeschlin; André R. Chaperon; Virginie Charbonneau; Luke G. Green; Steven V. Ley; Ulrich Lücking; Eric Walther
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 151 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0044-8249
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## Abstract The first total synthesis of a glycosylphosphatidylinositol (GPI) anchor bearing a polyunsaturated arachidonoyl fatty acid is reported. This lipid is found in mammalian GPIs that do not undergo lipid remodeling, a process that has important implications in the localization and function
Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou