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Semisynthesis and Characterization of Mammalian Thioredoxin Reductase †

✍ Scribed by Eckenroth, Brian; Harris, Katharine; Turanov, Anton A.; Gladyshev, Vadim N.; Raines, Ronald T.; Hondal, Robert J.

Book ID
126323747
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
364 KB
Volume
45
Category
Article
ISSN
0006-2960

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## Abstract Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox‐active disulfide bond of thioredoxin (Trx) and is similar in structure and mechanism to glutathione reductase except for a __C__‐terminal 16‐amino acid extension containing a rare vicinal selenylsulfide bond. This