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Small molecule inhibitors of mammalian thioredoxin reductase

โœ Scribed by Wenqing Cai; Liangwei Zhang; Yanlin Song; Baolin Wang; Baoxin Zhang; Xuemei Cui; Guanming Hu; Yaping Liu; Jincai Wu; Jianguo Fang


Book ID
113632526
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
988 KB
Volume
52
Category
Article
ISSN
0891-5849

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## Abstract Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redoxโ€active disulfide bond of thioredoxin (Trx) and is similar in structure and mechanism to glutathione reductase except for a __C__โ€terminal 16โ€amino acid extension containing a rare vicinal selenylsulfide bond. This