## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slowโbinding, highโaffin
โฆ LIBER โฆ
Self-Splicing and Enzymatic Activity of an Intervening Sequence RNA fromTetrahymena
โ Scribed by Thomas R. Cech
- Book ID
- 106372559
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 494 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0144-8463
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hexon) mRNA using R-looping with restriction fragments of the adenovirus 2 genome. Late in infection, most RNA on polysomes is viral and hexon mRNA is the most abundant species. Rlooping exploits the higher melting temperature of RNA : DNA than DNA : DNA duplexes, using electron microscopy to visual