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Self-reactive antibodies (natural autoantibodies) in healthy individuals

✍ Scribed by Sébastien Lacroix-Desmazes; Srini V Kaveri; Luc Mouthon; Ahidjo Ayouba; Evelyne Malanchère; Antonio Coutinho; Michel D Kazatchkine

Book ID
114052002
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
375 KB
Volume
216
Category
Article
ISSN
0022-1759

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Natural autoantibodies and complement pr
Natural autoantibodies and complement promote the uptake of a self antigen, human thyroglobulin, by B cells and the proliferation of thyroglobulin-reactive CD4+ T cells in healthy individuals
✍ Claus H. Nielsen; R. Graham Q. Leslie; Bettina S. Jepsen; Michel D. Kazatchkine; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 152 KB 👁 2 views

Serum from normal individuals contains substantial amounts of natural antibodies (NA) capable of recognizing self antigens. However, the physiological implications of this autoreactivity remain unclear. We have examined the role of self-reactive NA and complement in mediating the uptake of human thy