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Self-diffusion in CNS tissue by volume-selective proton NMR

✍ Scribed by Mark A. Horsfield; Gareth J. Barker; W. Ian McDonald

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
897 KB
Volume
31
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

We have used a volume‐selective NMR pulse sequence to measure the diffusion coefficient (D) inside a selected cuboid volume. The sequence is a variant of the stimulated echo method for volume‐selective spectroscopy, and allows sequential measurement of D in any of three orthogonal directions and for a range of diffusion times. The echo attenuation from which D is calculated is free from the cross terms that can arise because of interactions between volume selection and diffusion‐sensitizing gradients. Anisotropic and diffusion‐time‐dependent behavior is observed in brain structures known to have axon fibers aligned primarily in one direction.

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✍ Klaus-Dietmar Merboldt; Dirk Hörstermann; Wolfgang Hänicke; Harald Bruhn; Jens F 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 418 KB 👁 1 views

## Abstract Molecular self‐diffusion coefficients of water (0.75 ± 0.05), Nacetylaspartate (0.27 ± 0.04), creatines (0.27 ± 0.04), and cholines (0.28 ± 0.08) × 10^−5^ cm^2^ s^−1^ were obtained from localized proton NMR spectra of rat brain in vivo using diffusion‐weighted stimulated‐echo (STEAM) se