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Selenocysteine in Native Chemical Ligation and Expressed Protein Ligation

โœ Scribed by Hondal, Robert J.; Nilsson, Bradley L.; Raines, Ronald T.


Book ID
126985107
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
55 KB
Volume
123
Category
Article
ISSN
0002-7863

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Selenocysteine-Mediated Native Chemical
โœ Richard Quaderer; Axel Sewing; Donald Hilvert ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 108 KB

C-Terminal peptide thioesters are shown to react efficiently with peptide fragments containing an Nterminal selenocysteine to give selenoproteins. In analogy to the native chemical ligation of thioesters and peptides containing N-terminal cysteines, the selenol presumably attacks the thioester nucle