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Selenium and GPx-1 overexpression protect mammalian cells against UV-induced DNA damage

✍ Scribed by Manjeshwar S. Baliga; Hengbing Wang; Pin Zhuo; Jeffrey L. Schwartz; Alan M. Diamond


Book ID
110625653
Publisher
Humana Press Inc
Year
2007
Tongue
English
Weight
287 KB
Volume
115
Category
Article
ISSN
0163-4984

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Although oxygen is required for normal aerobic respiration, hyperoxia (95% O(2)/5% CO(2)) damages DNA, inhibits proliferation in G1, S and G2 phases of the cell cycle, and induces necrosis. The current study examines whether growth arrest in G1 protects pulmonary epithelial cells from oxidative DNA