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BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell death

โœ Scribed by Han K. Ho; Zhong-Hua Hu; Shie-Pon Tzung; David M. Hockenbery; Nelson Fausto; Sidney D. Nelson; Sam A. Bruschi


Book ID
113487398
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
417 KB
Volume
69
Category
Article
ISSN
0006-2952

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Although oxygen is required for normal aerobic respiration, hyperoxia (95% O(2)/5% CO(2)) damages DNA, inhibits proliferation in G1, S and G2 phases of the cell cycle, and induces necrosis. The current study examines whether growth arrest in G1 protects pulmonary epithelial cells from oxidative DNA