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Selenium and cancer: Effects of selenium and of the diet on the genesis of spontaneous mammary tumors in virgin inbred female C3H/St mice

✍ Scribed by G.N. Schrauzer; D.A. White; C.J. Schneider

Publisher
Elsevier Science
Year
1978
Weight
446 KB
Volume
8
Category
Article
ISSN
0006-3061

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✦ Synopsis

Inbred female CaH/St mice exhibit the normal incidence of spontaneous mammary adenocarcinoma of 80-100% if they are maintained on a standard commercial laboratory diet containing 0.15 ppm of selenium with meat and dried skimmed milk as major sources of protein. The tumor incidence drops to 42% if animals of the same strain are kept on a diet containing 0.45 ppm of selenium, with fishmeal as the main source of protein. The tumor incidence declines fu~ther to 25, 19 and 10% if the animals in addition receive 0.1, 0.5, and 1.0 ppm of selenium in the drinking water. Selenium supplementation at these levels has no noticable adverse effects on weight-gains and survival of the mice. Selenium supplemented groups of animals also remained tumor-free for

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