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Arsenic and Cancer: Effects of Joint Administration of Arsenite and Selenite on the Genesis of Mammary Adenocarcinoma in Inbred Female C3H/St Mice

✍ Scribed by G.N. Schrauzer; D.A. White; J.E. Mcginness; C.J. Schneider; L.J. Bell

Publisher: Elsevier Science
Year: 1978
Weight: 407 KB
Volume: 9
Category: Article
ISSN: 0006-3061
DOI: 10.1016/s0006-3061(78)80005-2

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✦ Synopsis

The joint administration of 2 ppm of arsenic as arsenite and of 2 ppm of selenium as selenite in the drinking water of inbred female C3H/St mice increases the incidence of spontaneous mammary adenocarcinoma significantly over the simultaneous controls and animals receiving 2 ppm As as arsenite or 2 ppm Se as selenite alone, indicating that arsenic abolishes the anticarcinogenic effect of selenium. Arsenite caused a significant increase of the tumor growth rates and raised the incidence of multiple tumors. The tumor growth rates in the As-Se group were also increased, but the incidence of multiple tumors was lower than in the 2 ppm As group.

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