Selegiline in the treatment of Parkinson's disease: its impact on orthostatic hypotension
โ Scribed by K.F. Bhattacharya; S. Nouri; C.W. Olanow; M.D. Yahr; H. Kaufmann
- Book ID
- 117751831
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 94 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1353-8020
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๐ SIMILAR VOLUMES
## Abstract There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety
Selegiline (10 mg per day) selectively inhibits monoamine oxidase type B and thus thwarts the metabolism of dopamine by this enzyme. Selegiline has been used in the therapy of Parkinson's disease since 1986. It enhances the efficacy of levodopa, allows a reduction of the levodopa dose, and improves