✦ LIBER ✦

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

✍ Scribed by Kerrie L. Schoffer; Robert D. Henderson; Karen O'Maley; John D. O'Sullivan

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 94 KB
Volume: 22
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.21428

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double‐blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS‐OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS‐OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect. © 2007 Movement Disorder Society

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