We have evaluated the relationship between MHC class-I, c-myc and c-fos proto-oncogene expression in several clones of a methylcholanthrene-induced fibrosarcoma (GR9) which originated in a BALBIc mouse. These clones represent a heterogeneous population and differ markedly with regard to H-2 class-I
Selective upregulation of MHC class I expression in metastatic colonies derived from tumor clones of a murine fibrosarcoma
β Scribed by S. Pedrinaci; A. Garcia Lora; M. Perez; F. Garrido; I. Algarra; J. J. Gaforio; F. Garrido
- Book ID
- 106194939
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 727 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0940-5437
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## Abstract GR9 is a chemically induced fibrosarcoma composed of clones with different Hβ2 classβI expression. These clones differ with respect to local growth and spontaneous metastasis. The B9 clone (Hβ2 negative) is highly tumorigenic (local growth) but of low metastatic potential (spontaneous m
We have examined the metastatic capacity of different clones of a chemically induced fibrosarcoma GR9. These clones have previously been characterized for their H-2 class-I and class4 phenotype, NK sensitivity and local tumor growth. Our present data show that clones which express low amounts of H-2