Differential mRNA levels of c-myc, c-fos and MHC class I in several clones of a murine fibrosarcoma

✍ Scribed by J. J. Gaforio; M. Pérez; I. Algarra; M. J. Mialdea; H. G. Ljunggren; F. Garrido

• Book ID: 102864196
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: French
• Weight: 663 KB
• Volume: 49
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910490618

✦ Synopsis

We have evaluated the relationship between MHC class-I, c-myc and c-fos proto-oncogene expression in several clones of a methylcholanthrene-induced fibrosarcoma (GR9) which originated in a BALBIc mouse. These clones represent a heterogeneous population and differ markedly with regard to H-2 class-I cell-surface expression, local tumor growth, NK sensitivity and metastatic potential. In the present study we show that cellsurface expression of MHC class-I antigens correlates inversely with levels of c-myc mRNA transcripts, On the other hand, mRNA levels of c-fos are correlated directly with the amount of mRNA of MHC class 1. Treatment of the B9 clone with gamma interferon increased mRNA transcription and surface expression of H-2 class-I antigens, while c-myc transcription was simultaneously down-regulated. In contrast, c-fos mRNA levels remained unaltered.