The phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the calcium ionophore, A23187, have similar effects on many different cells. For example, both show mitogenic and comitogenic activities for lymphocytes. It had been suggested that some of TPA's effects are due to its ab
✦ LIBER ✦
Modulation of c-fos and c-myc mRNA levels in normal human lymphocytes by calcium ionophore A23187 and phorbol ester
✍ Scribed by J. David Grausz; Didier Fradelizi; François Dautry; Roger Monier; Pierre Lehn
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 582 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0014-2980
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I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine