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Selective targeting of K-ras mutated colon cancer cells

✍ Scribed by Dvory-Sobol, H.; Kunik, T.; Kazanov, D.; Rozenblat, M.; Cohen Noyman, E.; Liberman, E.; Arber, N.


Book ID
122491436
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
349 KB
Volume
124
Category
Article
ISSN
0016-5085

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Fifty percent of human colon carcinomas contain activating mutations in the K-ras gene. However, whether these alterations in K-ras affect the function of Ras proteins in growth factor (GF) signal transduction is not known. Here we have characterized a previously defined human colon carcinoma cell m