Association of K-ras mutations with p16 methylation in human colon cancer
✍ Scribed by Rong J. Guan*; ‡; Yineng Fu§; Peter R. Holt∥; Arthur B. Pardee‡
- Book ID
- 118521614
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 393 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0016-5085
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Fifty percent of human colon carcinomas contain activating mutations in the K-ras gene. However, whether these alterations in K-ras affect the function of Ras proteins in growth factor (GF) signal transduction is not known. Here we have characterized a previously defined human colon carcinoma cell m