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Selective Synthesis of Fused 1,4- and 1,2-Dihydropyridines by Domino Reactions of Arylamines, Acetylenedicarboxylate, Aldehydes, and Cyclic 1,3-Diketones

✍ Scribed by Jing Sun; Yan Sun; Hong Gao; Chao-Guo Yan

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 565 KB
Volume: 2011
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.201101198

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✦ Synopsis

Abstract

A practical procedure for the preparation of fused 1,4‐dihydropyridines was developed through the domino four‐component reactions of arylamines, acetylenedicarboxylate, aromatic aldehydes, and cyclic 1,3‐diketones in acetic acid. Unusual fused 1,2‐dihydropyridines can also be efficiently prepared by controlling the reaction conditions.

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