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Selective synthesis of 2-chloro-2,3-epoxy-2-oxazolines and isomeric 3-chloro-2-oxo-2-oxazolines

✍ Scribed by Jean Claude Combret; Abdelhamid Meghni; Didier Postaire; Jacques Tekin


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
219 KB
Volume
32
Category
Article
ISSN
0040-4039

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✦ Synopsis


The reaction of 2-dichloromethyl-4,4-dimethyl-2-oxazoline with carbonyl compounds in basic media has been investigated. Phase transfer catalysis allows fast and selective formation of 2-chloro-2,3-epoxy-2-oxazolines (with aliphatic aldehydes) or 3-chloro-2-oxo-2-oxazolines (mainly with ketones) in high yields.


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