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Selective suppression of the transcription of ribosomal genes in mouse-human hybrid cells

✍ Scribed by R. P. Perry; D. E. Kelley; U. Schibler; K. Huebner; C. M. Croce

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 656 KB
Volume: 98
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040980313

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Mouse‐human hybrid cells that preferentially segregate either mouse or human chromosomes were analyzed for their relative content of mouse and human rRNA genes and for their capacity to transcribe these genes. A distinctive Hind III restriction fragment containing 28S rRNA sequences was used to distinguish between mouse and human rDNA and a set of distinctive loop structures in the 45S pre‐rRNA was used to distinguish between mouse and human gene transcripts. Our results indicate that the genes of only one species are transcriptionally active in these hybrid cells, even though both sets of genes are present.

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