Cartilage-derived growth factor purified to homogeneity by affinity chromatography on columns of heparin-Sepharose was mitogenic for early passage bovine fetal chondrocytes. Hyaluronate and sulfated glycosaminoglycan synthesis in these cells was analyzed by differential enzymatic digestion of the gl
β¦ LIBER β¦
Selective stimulation of sulfated glycosaminoglycan synthesis by multiplication-stimulating activity, cartilage-derived factor and bone-derived growth factor
β Scribed by Kato, Yukio; Watanabe, Rinzo; Hiraki, Yuji; Suzuki, Fujio; Canalis, Ernesto; Raisz, Lawrence G.; Nishikawa, Katsuzo; Adachi, Kozaburo
- Book ID
- 122650187
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 580 KB
- Volume
- 716
- Category
- Article
- ISSN
- 0304-4165
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## Background: Various tumours exhibit glycosaminoglycan rich, and in particular hyaluronan rich matrices surrounding them that facilitate tumour growth and invasion. in many tumours, this matrix is predominantly synthesized by fibroblasts following stimulation by tumour cell-derived factors. ## O