Part 1 describes the case of a 74-year-old woman who experienced a worsening of her psychiatric condition shortly after commencing fluoxetine and was found to have a low serum sodium level. The clinical features of hyponatraemia and its causes are reviewed. Part 2 reviews the reports of hyponatraemi
Selective serotonin reuptake inhibitors in intellectual disability
β Scribed by Racusin, Robert ;Kovner-Kline, Kathleen ;King, Bryan H.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 118 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1080-4013
No coin nor oath required. For personal study only.
β¦ Synopsis
There is considerable evidence linking developmental pathology with serotonergic abnormalities. Individuals with mental retardation may be particularly susceptible to dysfunction in the serotonin system. The development of more selective drugs that modify serotonergic function appears to have provided an important treatment option for a number of target behaviors, especially those associated with anxiety and depression, in persons with intellectual disability. Clinicians treating this population need to be familiar with the pharmacology of these agents, known collectively as the selective serotonin reuptake inhibitors. This article reviews the pharmacokinetics and pharmacodynamics of these compounds, as well as their potential effects on the developing brain.
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Objective: Recent data suggest that serotonin selective reuptake inhibiter (SSRI) medication is useful in preventing relapse in weight-restored anorexics. Our clinical impression has been that SSRIs are not effective in patients who are underweight with anorexia nervosa. Method: In order to determin
## Abstract For Abstract see ChemInform Abstract in Full Text.
The psychopharmacological profiles of several selective serotonin reuptake inhibitors (SSRIs) were compared and their behavioural toxicity contrasted both to placebo and the tricyclic antidepressants dothiepin and amitriptyline. On measures of central nervous system arousal (critical flicker fusion)