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Selective reduction of ketoesters to hydroxyesters with the use of lithium aluminum hydride in the presence of silica gel

✍ Scribed by Yasuhiro Kamitori; Masaru Hojo; Ryōichi Masuda; Tatsuro Inoue; Tatsuo Izumi

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
222 KB
Volume
23
Category
Article
ISSN
0040-4039

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✦ Synopsis

Lithium aluminum hydride, in the presence of a small amount of silica gel, has been found to be a versatile and highly selective reagent for reduction of various ketoesters to the corresponding hydroxyesters in fair yields.

Recently we reported a series of new synthetic reactions l-7) with the use of silica gel as a versatile catalyst. In some of these reactions 2) silica gel was used by itself as a mild and therefore very selective Lewis acid catalyst.

In the other cases 1, 3-6) where silica gel was used in combination with other reagents

📜 SIMILAR VOLUMES

Lithium aluminum hydride on silica gel -
Lithium aluminum hydride on silica gel - selective reduction of ketones and carboxy esters in the presence of nitro and cyano groups
✍ Yasuhiro Kamitori; Masaru Hojo; Ryōichi Masuda; Tatsuro Inoue; Tatsuo Izumi 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 133 KB

Cyano and nitro groups were found not to be reduced by Zithiwn alwninwn hydride on silica gel and with the use of this reagent ketones and carboxy esters bearing cyano and nitro groups were successfuZZy converted into the corresponding cyano and nitro alcohols.