Selective isotopic labeling of a nitroxide spin label to enhance sensitivity for T2 oxymetry

Synthesis of 4-protio-3-carbamoyl-2,2,5,

Synthesis of 4-protio-3-carbamoyl-2,2,5,5-tetraperdeuteromethyl-3-pyrrolin-1-yloxy (mHCTPO): A selectively isotopically labeled compound for use in T2 spin label oxymetry

✍ Yawares J. Lin; Beverly A. Teicher; Howard J. Halpern 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 429 KB

## Abstract The title compound (mHCTPO) has been prepared to enhance sensitivity to molecular oxygen concentration in its Electron Spin Resonance (ESR) spectrum. The synthesis involved a novel variant of the traditional nitroxide synthesis leading to a much improved yield of mHCTPO over the several