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Synthesis of 4-protio-3-carbamoyl-2,2,5,5-tetraperdeuteromethyl-3-pyrrolin-1-yloxy (mHCTPO): A selectively isotopically labeled compound for use in T2 spin label oxymetry

✍ Scribed by Yawares J. Lin; Beverly A. Teicher; Howard J. Halpern

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
429 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The title compound (mHCTPO) has been prepared to enhance sensitivity to molecular oxygen concentration in its Electron Spin Resonance (ESR) spectrum. The synthesis involved a novel variant of the traditional nitroxide synthesis leading to a much improved yield of mHCTPO over the several steps of the synthesis. An enhancement of T~2~ spin label oxymetry with independent measurment of spin label concentration (from a spectral feature) has been observed. This molecule represents a new class of potentially valuable compounds for in vivo application and for imaging in ESR oxymetry.

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