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Selective intestinal decontamination increases serum and ascitic fluid C3 levels in cirrhosis

✍ Scribed by Jose Such; Dr. Carlos Guarner; German Soriano; Montserrat Teixidó; José Barrios; Francisco Tena; Carmen Méndez; Jaime Enríquez; José Luis Rodríguez; Francisco Vilardell

Book ID
102238118
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
433 KB
Volume
12
Category
Article
ISSN
0270-9139

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✦ Synopsis

Spontaneous bacterial peritonitis (SBP) is a severe and frequent complication of cirrhosis with a high mortality rate (1-4). SBP is probably related to several impaired defense mechanisms, such as depressed reticuloendothelial system phagocytic activity (5, 61, leukocyte dysfunction (7,8), reduced serum complement(9, 10) and low bactericidal activity of ascitic fluid (AF)

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We have studied the effect of methylglyoxal-bis (guanylhydrazone) (MGBG) and novobiocin on the accumulation of specific mRNAs in serum-stimulated ts13 cells (a temperature-sensitive mutant of the BHK cell line). The RNAs studied included: c-myc, v-ras, ornithine decarboxylase, P-actin, histone H3, a