‘meso-Selective’ functionalisation of N-
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Ryan A Bragg; Jonathan Clayden; Christel J Menet
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Article
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2002
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Elsevier Science
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French
⚖ 105 KB
Lithiation and methylation of amide and carbamate derivatives of a-methylbenzylamine proceeds with high diastereoselectivity in favour of meso bis-a-methylbenzylamine derivatives. Carboxylation of the intermediate organolithium is also diastereoselective, and with N-Boc p-methoxy-a-methylbenzylamine