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Selective Induction of Human Hepatic Cytochromes P450 2B6 and 3A4 by Metamizole

✍ Scribed by Saussele, T; Burk, O; Blievernicht, J K; Klein, K; Nussler, A; Nussler, N; Hengstler, J G; Eichelbaum, M; Schwab, M; Zanger, U M


Book ID
110020010
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
216 KB
Volume
82
Category
Article
ISSN
0009-9236

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The abilities of structural congeners of phenobarbital to induce immunoreactive hepatic cytochrome P450 2B (CYP2B) protein and associated catalytic activity (benzyloxyresorufin 0-dealkylation) in the male B6C3F1 mouse were examined. Interspecies differences in inducing ability were examined through