Selective enhancement of experimental rat brain tumors with Gd-TPPS

✍ Scribed by Kurt Bockhorst; Thomas Els; Mathias Hoehn-Berlage

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 657 KB
• Volume: 4
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.1880040334

✦ Synopsis

Abstract

The synthetic metalloporphyrin gadolinium (III)‐tetraphenylporphine sulfonate (TPPS) was successfully used as a contrast agent for in vivo magnetic resonance (MR) imaging of rat brain glioma. After injection of Gd‐TPPS, the signal intensity of experimental rat brain glioma distinctly increased on T1‐weighted MR images, an effect similar to that produced by the clinically applied MR imaging contrast agent gadolinium diethylenetriaminepentaacetic acid (DTPA). In contrast to other contrast agents studied (Gd‐DTPA, manganese [III]‐TPPS), Gd‐TPPS produced hypointensity in glioma on T2‐weighted images. The tumor‐selective accumulation of paramagnetic Gd‐TPPS in glioma shortened T1 by 53%, from 1,315 msec ± 199 to 628 msec ± 106, and T2 by 34%, from 86 msec ± 4 to 57 msec ± 5 (2 days after injection of 0.25 mmol/kg Gd‐TPPS). The relaxation times of normal cortex, striaturn, corpus callosum, and temporal muscle were not significantly affected. As a result, gliomas appeared hyperintense on T1‐weighted images and hypointense on T2‐weighted images. Owing to the strong effect of Gd‐TPPS on the T2 of glioma, normal brain tissue, tumor, and peritumorous edema could be distinguished on T2‐weighted images alone.