Selective Electrochemical Removal of Protecting Groups in Nucleotide Synthesis

✍ Scribed by Dr. Joachim Engels

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 244 KB
• Volume: 18
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.197901481

✦ Synopsis

I and I1 reacted on the carrier to form V (53% based on 11-gel polymer) and 111 and IV reacted on the carrier to give VI (24 % based on IV-gel polymer). V was again released from the carrier, purified, and combined with VI on the carrier to give the fully protected final product VII (32'x based on VI-gel polymer). The scheme of fragment syntheses and the formation of the fully protected sequence VIII has already been briefly described17!