Selective effect of doxorubicin suspended in lipiodol on VX2 carcinoma in rabbits

✍ Scribed by Toshiya Furuta; Takashi Kanematsu; Saburo Kakizoe; Kiezo Sugimachi

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 712 KB
• Volume: 39
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930390404

✦ Synopsis

When Lipiodol Ultra-Fluid (Lipiodol) was given through arteries feeding the tumor, this material was retained in the tumor. After mixing Lipiodol and doxorubicin (adriamycin; ADR), the effect of this antitumor agent on VX2 carcinoma inoculated into the hindlimb in 57 rabbits was investigated. Size of the tumor remarkably decreased in the rabbits treated with ADR 2 mg/kg suspended in Lipiodol and given through the femoral artery. Intraarterial injection of ADR 2 mg/kg alone led to a transient decrease in size of the tumor, but there was a regrowth. The result was comparable to a finding in a group in which half the dose of ADR (1 mg/kg) suspended in Lipiodol was given intraarterially. When ADR 2 mg/kg mixed with Lipiodol was injected directly into the tumor, growth of the tumor was not completely inhibited. Lipiodolized ADR has a prominent antitumor effect, and Lipiodol has the potential to be applied as a carrier of anticancer drugs.