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Selective Deprotection of Methanesulfonamides to Amines

✍ Scribed by Naito, Hiroyuki; Hata, Takeshi; Urabe, Hirokazu


Book ID
121185881
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
227 KB
Volume
12
Category
Article
ISSN
1523-7060

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ChemInform Abstract: Selective Deprotect
✍ C. A. COSTELLO; A. J. KREUZMAN; M. J. ZMIJEWSKI πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 27 KB πŸ‘ 1 views

The absolute requirement for deprotection of the title amines is a two-carbon spacer between the free carboxylate and the benzoyl amine, cf. compounds (Ib) and (Ic). No enzymatic deprotection occurs if the reactive carboxylate is blocked,